Authors : Mohammad Ebrahimi

Volume/Issue : Volume 11 - 2026, Issue 2 - February

Google Scholar : https://tinyurl.com/2uesbkkd

Scribd : https://tinyurl.com/yphb8svd

DOI : https://doi.org/10.38124/ijisrt/26feb178

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Abstract : The established paradigm of gene regulation—encompassing epigenetic, transcriptional, and post-translational control—provides a foundational yet incomplete model of cellular homeostasis. This article explores a theoretical expansion of this paradigm by integrating the concept of a dynamic, photonic-informational network operating within and between cells. This work employs a theoretical synthesis, critically examining and integrating two complementary models: the intracellular Nagl-Popp model of DNA-biophoton feedback and the organism-wide Quantum Homunculus (Quantuculus) model. The analysis focuses on constructing a coherent multi-scale framework where quantum-biophysical principles underpin biological regulation. The synthesis reveals a proposed multi-tiered regulatory system. At the cellular level, the Nagl-Popp model describes a cybernetic feedback loop where metabolic activity generates a coherent biophoton field that influences DNA conformation and gene expression, and vice-versa. At the organismal level, the Quantum Homunculus model emerges as a global, holographic network formed by the coupling of these intracellular biophoton fields, potentially coordinating activity across vast biological scales. This framework posits a continuous "DNA-Photome" network as a fundamental layer of biological information processing. The proposed integration of the Nagl-Popp and Quantum Homunculus models suggests a radical rethinking of the regulome, positioning coherent electromagnetic fields as a central pillar of biological coordination. If empirically validated, this framework promises to open new frontiers in fundamental research, such as mapping "photon signatures" of health and disease, and in translational medicine, enabling novel diagnostic platforms and information-based therapeutic strategies. It provides a testable hypothesis for the role of quantum coherence in living systems.

Keywords : DNA, Biophoton, Gene Regulation, DNA-Photon Network, Cybernetic Feedback, Nagl-Popp Model, Quantum Homunculus Models.

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