Interest in Entrepreneurship is an individual's desire to have a career as an entrepreneur. The study aimed to determine the effect of entrepreneurship education and the school environment on interest in entrepreneurship with self-efficacy as a mediation. Associative causality quantitative research with sampling technique using non-probability sampling, the saturated sample is 85 students of class XII Multimedia SMK XYZ. Technical analysis of data using path analysis method with SmartPLS version 3.2.9. The results of the study reveal that: (1) entrepreneurship education has a significant positive effect on self-efficacy and interest in entrepreneurship; (2) the school environment has a significant positive effect on selfefficacy and interest in entrepreneurship; (3) selfefficacy has a significant positive effect on the interest in entrepreneurship and (4) self-efficacy significantly mediates the entrepreneurship education variable and the school environment variable on the interest in entrepreneurship

Keywords : Entrepreneurship Education, School Environment, Self-Efficacy, Interest in Entrepreneurship