The Effect of Standarized Extract Pegagan Embun (Hydrocotyle sibthorpioides Lam.) on Total Leukocyte and Percentage Leukocytes in Male White Mice Exposed to H5N1 Virus Antigen

Authors : Fitratul Wahyuni; Yufri Aldi; Elidahanum Husni

Volume/Issue : Volume 6 - 2021, Issue 7 - July

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Pegagan embun has been used to increase endurance. In this study, the effects of Pegagan embun extract on the number and percentage of leukocyte cells exposed to the H5N1 antigen were observed. As many as 35 experimental animals were used, divided into 7 groups, by varying the time of administration of the H5N1 antigen. Groups 1 and 2, given the test extract for 7 days and induced H5N1 antigen on days 1 and 7 were evaluated on day 8. Group 3 was given a test extract for 3 days then induced antigen on day 4 and continued with giving the test extract until day 7. In groups 5 and 7, only H5N1 antigen induction was given on day 1 and evaluated on day 8 and day 5. Groups 4 and 6 were only given the test extract for 7 and 4 days. Observations were made on the total number and percentage of leukocyte cells. After being counted, the total leukocyte the presntase of leukocyte cell types the yield of eucinophils was . From the results of statistical analysis it can be concluded that giving Pegagan embun extract to male white mice exposed to the H5N1 antigen can increase the number of leukocytes and the percentage of leucocyte cell types that increase are neutrophil cells, eucinophils, and monocyte cells.

Keywords : Hydrocotyle sibthorpioides Lam.; Immunostimulan; Leukocyte percentage; Total leukocyte.


Paper Submission Last Date
31 - October - 2023

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