COVID-19 is still a global problem today. In addition to causing physical disturbances, it also causes psychological disorders and stressful conditions for patients suffering from COVID-19. This study aimed to analyze stress level, IL-10 level, albumin level, neutrophil values and NPAR on severity in COVID-19 patients. Methods: This study was an analytical observational study in a cohort prospective design. This research was conducted in June – September 2021, with patients who were confirmed to have COVID-19 in Infectious Emergency Department and Special Isolation Room of Dr. Soetomo General Hospital Surabaya as subjects. COVID-19 patients with mild, moderate and severe level according to WHO criteria 2020 were measured for stress level using DASS-21 questionnaire, interleukin level and also neutrophil and albumin level during treatment on the beginning of admission, the 3rd, 6th, and 12th day of admission.

Keywords : Stress level, IL-10, Neutrophil PercentageAlbumin Ratio, COVID-19 Severity.