Authors :
Wopara, Iheanyichukwu" Mobisson, Samuel Kelechi" Olusegun, G. Adebayo
Volume/Issue :
Volume 5 - 2020, Issue 4 - April
Google Scholar :
https://goo.gl/DF9R4u
Scribd :
https://bit.ly/355wNuU
Abstract :
This study investigated the impact of ethanol
root extract of Sphenocentrum jollyanum and Baphia
nitida on reproductive indices of seventy (70) male
Wistar albino rats(b.w 150 to 200g). The rats were
randomly grouped into seven of 10 rats per
group.Groups 1 and 2 were given 400mg/kg b.w of
S.jollyanum and B.nitida, groups 3 and 4 were given
400mg/kg and 200mg/kg b.w of combined mixture of
S.jollyanum and B.nitida, while groups 5 and 6 were
given 200mg/kg b.w of B.nitida and S.jollyanum extracts
respectively for 60 days and group 7 serves as
control.All rats were allowed access to feed and water
ad libitum.Results were analyzed using GRAPHPAD
PRISM in comparing difference among means and level
of significance set at p<0.05. There was significant
(p<0.05) decrease on serum follicle stimulating hormone
(FSH) in group given 400mg/kg of S.jollyanum
compared with control. Significant (p<0.05) increase
was observed in serum testosterone levels in groups two,
four and six compared with the control. Furthermore,
significant (p<0.05) decline was observed in progressive
motility of spermatozoa and total sperm count in
experimental groups compared to control. Sperm
viability did not show any significant change. However,
percentage of irregular spermatozoa was significantly
(p<0.05) elevated in experimental groups compared to
control. The result also showed down regulation of
glutathione reductase, peroxidase, catalase and nitric
oxide genes across experimental groups.These results
suggesta possible detrimental effect of these extractson
the reproductive function of male Wistar rats.
Keywords :
Sphenocentrum jollyanum, Baphia nitida, Follicle Stimulating Hormone, Testosterone and Antioxidant Enzymes.
This study investigated the impact of ethanol
root extract of Sphenocentrum jollyanum and Baphia
nitida on reproductive indices of seventy (70) male
Wistar albino rats(b.w 150 to 200g). The rats were
randomly grouped into seven of 10 rats per
group.Groups 1 and 2 were given 400mg/kg b.w of
S.jollyanum and B.nitida, groups 3 and 4 were given
400mg/kg and 200mg/kg b.w of combined mixture of
S.jollyanum and B.nitida, while groups 5 and 6 were
given 200mg/kg b.w of B.nitida and S.jollyanum extracts
respectively for 60 days and group 7 serves as
control.All rats were allowed access to feed and water
ad libitum.Results were analyzed using GRAPHPAD
PRISM in comparing difference among means and level
of significance set at p<0.05. There was significant
(p<0.05) decrease on serum follicle stimulating hormone
(FSH) in group given 400mg/kg of S.jollyanum
compared with control. Significant (p<0.05) increase
was observed in serum testosterone levels in groups two,
four and six compared with the control. Furthermore,
significant (p<0.05) decline was observed in progressive
motility of spermatozoa and total sperm count in
experimental groups compared to control. Sperm
viability did not show any significant change. However,
percentage of irregular spermatozoa was significantly
(p<0.05) elevated in experimental groups compared to
control. The result also showed down regulation of
glutathione reductase, peroxidase, catalase and nitric
oxide genes across experimental groups.These results
suggesta possible detrimental effect of these extractson
the reproductive function of male Wistar rats.
Keywords :
Sphenocentrum jollyanum, Baphia nitida, Follicle Stimulating Hormone, Testosterone and Antioxidant Enzymes.
