The Impact of Sphenocentrum jollyanum, Baphia natida and Combined Extract Consumption on Reproductive Indices and Antioxidants Gene of Male Wistar Rats

Authors : Wopara, Iheanyichukwu" Mobisson, Samuel Kelechi" Olusegun, G. Adebayo

Volume/Issue : Volume 5 - 2020, Issue 4 - April

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This study investigated the impact of ethanol root extract of Sphenocentrum jollyanum and Baphia nitida on reproductive indices of seventy (70) male Wistar albino rats(b.w 150 to 200g). The rats were randomly grouped into seven of 10 rats per group.Groups 1 and 2 were given 400mg/kg b.w of S.jollyanum and B.nitida, groups 3 and 4 were given 400mg/kg and 200mg/kg b.w of combined mixture of S.jollyanum and B.nitida, while groups 5 and 6 were given 200mg/kg b.w of B.nitida and S.jollyanum extracts respectively for 60 days and group 7 serves as control.All rats were allowed access to feed and water ad libitum.Results were analyzed using GRAPHPAD PRISM in comparing difference among means and level of significance set at p<0.05. There was significant (p<0.05) decrease on serum follicle stimulating hormone (FSH) in group given 400mg/kg of S.jollyanum compared with control. Significant (p<0.05) increase was observed in serum testosterone levels in groups two, four and six compared with the control. Furthermore, significant (p<0.05) decline was observed in progressive motility of spermatozoa and total sperm count in experimental groups compared to control. Sperm viability did not show any significant change. However, percentage of irregular spermatozoa was significantly (p<0.05) elevated in experimental groups compared to control. The result also showed down regulation of glutathione reductase, peroxidase, catalase and nitric oxide genes across experimental groups.These results suggesta possible detrimental effect of these extractson the reproductive function of male Wistar rats.

Keywords : Sphenocentrum jollyanum, Baphia nitida, Follicle Stimulating Hormone, Testosterone and Antioxidant Enzymes.


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