Authors : Aarnav Mishra

Volume/Issue : Volume 10 - 2025, Issue 11 - November

Google Scholar : https://tinyurl.com/5n8eej3f

Scribd : https://tinyurl.com/mrtyfprr

DOI : https://doi.org/10.38124/ijisrt/25nov259

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Abstract : This paper provides an in-depth review of the human microbiome and its profound influence on host physiology and disease. Defined as a complex "superorganism," this microbial ecosystem is critically involved in regulating metabolic, immune, and neurological functions. The primary objective of this review is to mechanistically dissect the intricate relationship between microbial dysbiosis—an imbalance in the microbial community—and the pathogenesis of chronic non- communicable diseases, with a specific focus on obesity, diabetes mellitus, and autoimmune conditions such as inflammatory bowel disease and rheumatoid arthritis. This analysis delves into the pivotal roles of microbial metabolites, the bidirectional gut-brain axis, and the gut-immune axis in disease development. It highlights key findings from a diverse range of research, including the paradoxical roles of short-chain fatty acids (SCFAs), the specific microbial signatures associated with distinct pathologies, and the compromised gut barrier as a unifying pathophysiological mechanism. The paper also summarizes the therapeutic potential of microbiome-targeted interventions, such as prebiotics, probiotics, and fecal microbiota transplantation, and underscores the critical need for a personalized medicine approach to translate this knowledge into effective clinical practice.

References :

1. Lynch, S. V., & Pedersen, O. (2016). The human intestinal microbiome in health and disease. New England Journal of Medicine.
2. Ursell, L. K., et al. (2012). Defining the human microbiome. Nutrition Reviews.
3. Flint, H. J., et al. (2007). The role of the gut microbiota in nutrition and health. Nature Reviews Microbiology.
4. Lozupone, C. A., et al. (2012). Diversity, stability and function of the human gut microbiome. Nature.
5. Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: The impact of the gut microbiota on brain and behavior. Nature Reviews Neuroscience.
6. Honda, K., & Littman, D. R. (2016). The microbiome in infectious disease and inflammation. Annual Review of Immunology.
7. Ley, R. E., et al. (2006). Microbial ecology: Human gut microbes associated with obesity. Nature.
8. Turnbaugh, P. J., et al. (2006). An obesity-associated gut microbiome with increased capacity for energy harvest. Nature.
9. Scott, K. P., et al. (2013). The gut microbiota as a source of short-chain fatty acids. Cell Metabolism.
10. Hamer, H. M., et al. (2008). The gut microbiota and its metabolic role in obesity. Best Pract Res Clin Gastroenterol.
11. Pindado, A. P., et al. (2015). The role of the gut microbiome in the development of type 1 diabetes. Clin Endocrinol (Oxf).
12. Vrieze, A., et al. (2012). Transfer of intestinal microbiota from lean donors to patients with metabolic syndrome improves insulin sensitivity. Gastroenterology.
13. Cani, P. D., & Delzenne, N. M. (2009). The role of the gut microbiota in metabolic diseases. Annu Rev Nutr.
14. Giongo, A., et al. (2011). Toward a clinical-grade microbiome-based diagnostic test for type 1 diabetes. J Clin Endocrinol Metab.
15. Furusawa, Y., et al. (2015). Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature.
16. Fasano, A. (2011). Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol.
17. Manichanh, C., et al. (2006). Reduced diversity of faecal microbiota in Crohn's disease. Gut.
18. Sokol, H., et al. (2008). Faecalibacterium prausnitzii is decreased in Crohn's disease patients and is associated with intestinal inflammation. Inflamm Bowel Dis.
19. Miquel, S., et al. (2013). Faecalibacterium prausnitzii and its effects on intestinal inflammation. Microbes Infect.
20. Scher, J. U., et al. (2015). The gut microbiome and arthritis. Arthritis Rheum.
21. Burokas, A., et al. (2017). Microbiota regulation of the gut-brain axis. Nature Reviews Gastroenterology & Hepatology.
22. Round, J. L., et al. (2014). The gut microbiome and inflammatory diseases. Nature Reviews Immunology.