Authors : Ameh Simon Sunday; Egwim Chidi Evans; Muhammad Fatima Mahmoud; Aboyeji David Oyeyemi; Blankson Adenike Tinuke; Alhassan Jibrin Dabban; Onuekwusi Chukwuebuka Emmanuel; Osisami Olubukunola Folashade

Volume/Issue : Volume 11 - 2026, Issue 1 - January

Google Scholar : https://tinyurl.com/35vesup7

Scribd : https://tinyurl.com/u7e88d8a

DOI : https://doi.org/10.38124/ijisrt/26jan1036

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Lactoferrin, an iron-binding glycoprotein predominantly found in milk, has gained significant attention for its diverse roles in health and nutrition. This review explores the multifaceted applications of lactoferrin, emphasizing its pharmacological benefits, nutritional properties, and potential therapeutic uses. In biomedicine, lactoferrin exhibits antimicrobial, antiviral, and anti-inflammatory activities, playing a crucial role in immune modulation and gut health. Its ability to enhance iron absorption and support microbiota balance positions it as a valuable dietary supplement in nutrition. Additionally, the incorporation of lactoferrin into functional foods and beverages offers promising avenues for improving public health outcomes. This review aims to synthesize current research on lactoferrin's mechanisms of action, its applications in clinical and dietary contexts, and future directions for research and development. By highlighting the importance of lactoferrin in both health and nutrition, this review underscores its potential as a key component in preventive healthcare strategies.

Keywords : Lactoferrin, Glycoprotein, Nutrition.

References :

1. Shini, V. S., Udayarajan, C. T., & Nisha, P. (2022). A comprehensive review on lactoferrin: A natural multifunctional glycoprotein. Food & function, 13(23), 11954-11972.
2. Kell, D. B., Heyden, E. L., & Pretorius, E. (2020). The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria. Frontiers in immunology, 11, 550441.
3. Artym, J., Zimecki, M., & Kruzel, M. L. (2021). Lactoferrin for prevention and treatment of anemia and inflammation in pregnant women: a comprehensive review. Biomedicines, 9(8), 898.
4. Chasteen, N. D., & Woodworth, R. C. (2024). Transferrin and lactoferrin. In Iron transport and storage (pp. 67-79). CRC Press.
5. Ashraf, M. F., Zubair, D., Bashir, M. N., Alagawany, M., Ahmed, S., Shah, Q. A., ... & Arain, M. A. (2024). Nutraceutical and health-promoting potential of lactoferrin, an iron-binding protein in human and animal: current knowledge. Biological Trace Element Research, 202(1), 56-72.
6. Koletzko, B., Brands, B., Poston, L., Godfrey, K., & Demmelmair, H. (2012). Early nutrition programming of long-term health. Proceedings of the nutrition Society, 71(3), 371-378.
7. Kariyawasam, K. P., Somaratne, G., Dillimuni, S. D., & Walallawita, U. (2025). Comparative Analysis of Breastfeeding and Infant Formulas: Short‐and Long‐Term Impacts on Infant Nutrition and Health. Food Science & Nutrition, 13(9), e70788.
8. Zhao, X., Xu, X. X., Liu, Y., Xi, E. Z., An, J. J., Tabys, D., & Liu, N. (2019). The in vitro protective role of bovine lactoferrin on intestinal epithelial barrier. Molecules, 24(1), 148.
9. Shahramian, I., Kalvandi, G., Javaherizadeh, H., Khalili, M., Noori, N. M., Delaramnasab, M., & Bazi, A. (2018). The effects of prebiotic supplementation on weight gain, diarrhoea, constipation, fever and respiratory tract infections in the first year of life. Journal of paediatrics and child health, 54(8), 875-880.
10. Bakshi, S., Paswan, V. K., Yadav, S. P., Bhinchhar, B. K., Kharkwal, S., Rose, H., ... & Bunkar, D. S. (2023). A comprehensive review on infant formula: Nutritional and functional constituents, recent trends in processing and its impact on infants’ gut microbiota. Frontiers in Nutrition, 10, 1194679.
11. Zakaria, A. M., Zakaria, H. M., Abdelhiee, E. Y., Fadl, S. E., & Ombarak, R. (2020). The impact of lactoferrin fortification on the health benefits and sensory properties of yogurt. Journal of Current Veterinary Research, 2(2), 105-112.
12. Lin, Y., Song, S., & Guo, H. (2025). Recent advances in synergistic effect of lactoferrin. Current Opinion in Food Science, 101285.
13. Orsi, N. (2004). The antimicrobial activity of lactoferrin: current status and perspectives. Biometals, 17(3), 189-196.
14. Avalos-Gómez, C., Aguilar-Chaparro, M. A., Ríos-Castro, E., Marin-Flamand, E., Sánchez-Mendoza, A. E., & de la Garza, M. (2025). Differences between protein cargo in outer membrane vesicles released from Mannheimia haemolytica A2 in the presence and absence of bovine lactoferrin. Journal of Proteomics, 105550.
15. Roșeanu, A., Damian, M., & Evans, R. W. (2010). Mechanisms of the antibacterial activity of lactoferrin and lactoferrin-derived peptides.
16. Coccolini, C., Berselli, E., Blanco-Llamero, C., Fathi, F., Oliveira, M. B. P., Krambeck, K., & Souto, E. B. (2023). Biomedical and nutritional applications of lactoferrin. International Journal of Peptide Research and Therapeutics, 29(5), 71.
17. Malanovic, N., & Lohner, K. (2016). Antimicrobial peptides targeting gram-positive bacteria. Pharmaceuticals, 9(3), 59.
18. Eker, F., Duman, H., Ertürk, M., & Karav, S. (2024). The potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases. Frontiers in immunology, 15, 1402135.
19. González-Chávez, S. A., Arévalo-Gallegos, S., & Rascón-Cruz, Q. (2009). Lactoferrin: structure, function and applications. International journal of antimicrobial agents, 33(4), 301-e1.
20. Berlutti, F., Pantanella, F., Natalizi, T., Frioni, A., Paesano, R., Polimeni, A., & Valenti, P. (2011). Antiviral properties of lactoferrin—a natural immunity molecule. Molecules, 16(8), 6992-7018.
21. Gruden, Š., & Poklar Ulrih, N. (2021). Diverse mechanisms of antimicrobial activities of lactoferrins, lactoferricins, and other lactoferrin-derived peptides. International journal of molecular sciences, 22(20), 11264.
22. Pietrantoni, A., Dofrelli, E., Tinari, A., Ammendolia, M. G., Puzelli, S., Fabiani, C., ... & Superti, F. (2010). Bovine lactoferrin inhibits influenza A virus induced programmed cell death in vitro. Biometals, 23(3), 465-475.
23. Eker, F., Duman, H., Ertürk, M., & Karav, S. (2024). The potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases. Frontiers in immunology, 15, 1402135.
24. Brummerhop, A. S., Lee, C. T., Weltman, R., Tribble, G. D., van der Hoeven, R., Chiu, Y., ... &   Wang, B. Y. (2024). Synergistic effects of antimicrobial components of the human-derived composite amnion-chorion membrane on bacterial growth. Frontiers in cellular and infection microbiology, 14, 1472737.
25. Li, B., Zhang, B., Liu, X., Zheng, Y., Han, K., Liu, H., ... & Liu, X. (2022). The effect of lactoferrin in aging: role and potential. Food & Function, 13(2), 501-513.
26. Demir, R., Sarıtaş, S., Bechelany, M., & Karav, S. (2025). Lactoferrin: Properties and potential uses in the food industry. International Journal of Molecular Sciences, 26(4), 1404.
27. Memon, I. A., Jamal, A., Memon, H., & Parveen, N. (2009). Intestinal amoebiasis in children and its effect on nutritional status. J Coll Physicians Surg Pak, 19(7), 440-443.
28. Reyes-López, M., Ramírez-Rico, G., Serrano-Luna, J., & de la Garza, M. (2022). Activity of Apo-  Lactoferrin on pathogenic protozoa. Pharmaceutics, 14(8), 1702.
29. Anand, N. (2024). Antiparasitic activity of the iron-containing milk protein lactoferrin and its potential derivatives against human intestinal and blood parasites. Frontiers in Parasitology, 2, 1330398.
30. Cutone, A., Rosa, L., Ianiro, G., Lepanto, M. S., Bonaccorsi di Patti, M. C., Valenti, P., & Musci, G. (2020). Lactoferrin’s anti-cancer properties: Safety, selectivity, and wide range of action. Biomolecules, 10(3), 456.
31. Bukowska-Ośko, I., Sulejczak, D., Kaczyńska, K., Kleczkowska, P., Kramkowski, K., Popiel, M., ... & Kowalczyk, P. (2022). Lactoferrin as a human genome “guardian”—An overall point of view. International Journal of Molecular Sciences, 23(9), 5248.
32. Rascón-Cruz, Q., Espinoza-Sánchez, E. A., Siqueiros-Cendón, T. S., Nakamura-Bencomo, S. I., Arévalo-Gallegos, S., & Iglesias-Figueroa, B. F. (2021). Lactoferrin: A glycoprotein involved in immunomodulation, anticancer, and antimicrobial processes. Molecules, 26(1), 205.
33. Coccolini, C., Berselli, E., Blanco-Llamero, C., Fathi, F., Oliveira, M. B. P., Krambeck, K., & Souto, E. B. (2023). Biomedical and nutritional applications of lactoferrin. International Journal of Peptide Research and Therapeutics, 29(5), 71.