Authors :
Norhanifah C. Didato; Junnin Gay L. Garay; Vera Marie T. Gonesto; Patricia Mae B. Jarabe; Norjannah D. Palawan
Volume/Issue :
Volume 10 - 2025, Issue 7 - July
Google Scholar :
https://tinyurl.com/3ma5rah5
Scribd :
https://tinyurl.com/428sbnm9
DOI :
https://doi.org/10.38124/ijisrt/25jul538
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Abstract :
This study investigated the wound-healing efficacy of Mussaenda philippica leaf extract, a plant traditionally
used for wound management. Methanol-extracted leaf compounds were formulated into topical ointments at 1%, 5%, and
10% concentrations and tested on excised wounds in male mice, with 10% povidone-iodine and plain ointment serving as
positive and negative controls, respectively. Phytochemical analysis identified tannins, flavonoids, and saponins-bioactive
compounds associated with healing mechanisms. Acute toxicity assessments demonstrated no adverse effects, confirming
the extract’s safety.
The 10% formulation exhibited the most potent wound-healing activity, achieving complete epithelialization within
14 days, comparable to the 10% povidone-iodine group. The 5% concentration also showed significant efficacy,
outperforming the negative control, while the 1% formulation demonstrated minimal therapeutic impact. These findings
validate M. philippica’s traditional use and suggest its potential as a safe, cost-effective alternative to synthetic wound care
agents. Further pharmacological and clinical studies are recommended to optimize dosage and evaluate translational
applicability in humans.
Keywords :
Mussaenda Philippica; Wound Healing; Plant Extract; Mice; Traditional Medicine.
References :
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- G/Giorgis SG, Ambikar D, Tsegaw A, Belayneh YM. Wound Healing Activity of 80% Methanolic Crude Extract and Solvent Fraction of the Leaves of Justicia achimperiana (Hochst. Ex Nees) T. Anderson (Acanthaceae) in Mice. Journal of Experimental Pharmacology. 2022;Volume 14:167-183.http//doi.org/10.2147/jep.s340177
- Gilliver SC, Ashworth JJ, Ashcroft GS.2017. The hormonal regulation of cutaneous wound healing. Clin Dermatol. 25(1):56-62.
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- Umoh RA, Johnny II, Andy NA, Udoh AE, Ekpo TE, Ashibeshi GU. 2023. Micromorphological and Pharmacognostic Studies of Mussaenda philippica L. Flower. Journal of Complementary and Alternative Medical Research. 23(4):1–11. doi:10.9734/jocamr/2023/v23i4483.
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This study investigated the wound-healing efficacy of Mussaenda philippica leaf extract, a plant traditionally
used for wound management. Methanol-extracted leaf compounds were formulated into topical ointments at 1%, 5%, and
10% concentrations and tested on excised wounds in male mice, with 10% povidone-iodine and plain ointment serving as
positive and negative controls, respectively. Phytochemical analysis identified tannins, flavonoids, and saponins-bioactive
compounds associated with healing mechanisms. Acute toxicity assessments demonstrated no adverse effects, confirming
the extract’s safety.
The 10% formulation exhibited the most potent wound-healing activity, achieving complete epithelialization within
14 days, comparable to the 10% povidone-iodine group. The 5% concentration also showed significant efficacy,
outperforming the negative control, while the 1% formulation demonstrated minimal therapeutic impact. These findings
validate M. philippica’s traditional use and suggest its potential as a safe, cost-effective alternative to synthetic wound care
agents. Further pharmacological and clinical studies are recommended to optimize dosage and evaluate translational
applicability in humans.
Keywords :
Mussaenda Philippica; Wound Healing; Plant Extract; Mice; Traditional Medicine.
