Authors :
Dr. Akshaya Doddamani; Dr. Amulya B; Dr. Sudha R; Dr. Madhurima R; Dr. Venugopal Reddy.I
Volume/Issue :
Volume 9 - 2024, Issue 10 - October
Google Scholar :
https://tinyurl.com/3c6p9pjy
Scribd :
https://tinyurl.com/zb5ku5cx
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24OCT1358
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
The vaginal microbiome plays a critical role in
maintaining vaginal health during pregnancy and is
strongly linked to adverse pregnancy outcomes, including
preterm birth and preeclampsia. The composition and
diversity of the microbiome fluctuate throughout
pregnancy, influenced by hormonal changes,
environmental factors, and lifestyle. Recent studies have
highlighted the importance of certain microbiota,
particularly Lactobacillus species, in protecting against
infections and inflammation. Conversely, dysbiosis,
characterized by a decrease in Lactobacillus dominance,
has been associated with an increased risk of preterm
birth and preeclampsia. This article explores the current
understanding of the vaginal microbiome in pregnancy,
its role in preventing pregnancy complications, and future
research directions for improving maternal and fetal
health.
Keywords :
Microbiome, Pregnancy, Vaginal Health, Preterm Birth, Preeclampsia, Lactobacillus, Dysbiosis
References :
- DiGiulio, D. B., et al. (2015). Temporal and spatial variation of the human microbiota during pregnancy. Proceedings of the National Academy of Sciences, 112(35), 11060-11065.
- Klebanoff, M. A., et al. (2018). Probiotics and preterm birth: A randomized controlled trial. American Journal of Obstetrics and Gynecology, 219(6), 617.e1-617.e7.
- Payne, M. S., et al. (2018). Vaginal microbiome, preterm birth, and preeclampsia: A review of current knowledge. Journal of Reproductive Immunology, 125, 35-41.
- Donders, G. G. G., et al. (2020). The vaginal microbiota and preeclampsia: A systematic review and meta-analysis. Journal of Maternal-Fetal & Neonatal Medicine, 33(23), 3920-3928.
- Ravel, J., et al. (2011). Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences, 108(Supplement 1), 4680-4687.
- Romero, R., et al. (2014). The composition and stability of the vaginal microbiota in pregnant women. Journal of Reproductive Immunology, 104-105, 120-131.
- MOMS-PI Study. (2019). The role of vaginal microbiota in preterm birth: Insights from a large cohort study. American Journal of Obstetrics and Gynecology, 221(2), 136.e1-136.e15.
- DiGiulio, D. B., et al. (2015). Microbial invasion of the amniotic cavity is associated with preterm labor and neonatal sepsis. American Journal of Obstetrics and Gynecology, 213(6), 845-855.
- Martin, D. H., et al. (2018). The role of vaginal microbiota in pregnancy complications: Current perspectives. Journal of Reproductive Medicine, 63(3), 203-211.
- Romero, R., et al. (2014). Intra-amniotic infection and the microbiome in preterm labor. American Journal of Obstetrics and Gynecology, 210(1), 10-15.
- Ravel, J., et al. (2011). Vaginal microbiome dynamics in healthy pregnancy and adverse outcomes. The Lancet Infectious Diseases, 11(3), 203-213.
- Chaban, B., et al. (2014). Characterization of the vaginal microbiota in women with preterm birth: A comparison with women in term birth. PLoS ONE, 9(11), e112434.
- Wylie, K. M., et al. (2018). The vaginal microbiome and adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology, 218(3), 324-334.
- Romero, R., et al. (2014). The role of inflammation and infection in preterm birth. Seminars in Reproductive Medicine, 32(1), 22-29.
- MacIntyre, D. A., et al. (2015). The vaginal microbiome during pregnancy and preterm birth. Reproductive Sciences, 22(7), 906-914.
The vaginal microbiome plays a critical role in
maintaining vaginal health during pregnancy and is
strongly linked to adverse pregnancy outcomes, including
preterm birth and preeclampsia. The composition and
diversity of the microbiome fluctuate throughout
pregnancy, influenced by hormonal changes,
environmental factors, and lifestyle. Recent studies have
highlighted the importance of certain microbiota,
particularly Lactobacillus species, in protecting against
infections and inflammation. Conversely, dysbiosis,
characterized by a decrease in Lactobacillus dominance,
has been associated with an increased risk of preterm
birth and preeclampsia. This article explores the current
understanding of the vaginal microbiome in pregnancy,
its role in preventing pregnancy complications, and future
research directions for improving maternal and fetal
health.
Keywords :
Microbiome, Pregnancy, Vaginal Health, Preterm Birth, Preeclampsia, Lactobacillus, Dysbiosis