The Role of Microbiome in Pregnancy: Exploring Links Between Vaginal Health, Preterm Birth, and Preeclampsia


Authors : Dr. Akshaya Doddamani; Dr. Amulya B; Dr. Sudha R; Dr. Madhurima R; Dr. Venugopal Reddy.I

Volume/Issue : Volume 9 - 2024, Issue 10 - October


Google Scholar : https://tinyurl.com/3c6p9pjy

Scribd : https://tinyurl.com/zb5ku5cx

DOI : https://doi.org/10.38124/ijisrt/IJISRT24OCT1358

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : The vaginal microbiome plays a critical role in maintaining vaginal health during pregnancy and is strongly linked to adverse pregnancy outcomes, including preterm birth and preeclampsia. The composition and diversity of the microbiome fluctuate throughout pregnancy, influenced by hormonal changes, environmental factors, and lifestyle. Recent studies have highlighted the importance of certain microbiota, particularly Lactobacillus species, in protecting against infections and inflammation. Conversely, dysbiosis, characterized by a decrease in Lactobacillus dominance, has been associated with an increased risk of preterm birth and preeclampsia. This article explores the current understanding of the vaginal microbiome in pregnancy, its role in preventing pregnancy complications, and future research directions for improving maternal and fetal health.

Keywords : Microbiome, Pregnancy, Vaginal Health, Preterm Birth, Preeclampsia, Lactobacillus, Dysbiosis

References :

  1. DiGiulio, D. B., et al. (2015). Temporal and spatial variation of the human microbiota during pregnancy. Proceedings of the National Academy of Sciences, 112(35), 11060-11065.
  2. Klebanoff, M. A., et al. (2018). Probiotics and preterm birth: A randomized controlled trial. American Journal of Obstetrics and Gynecology, 219(6), 617.e1-617.e7.
  3. Payne, M. S., et al. (2018). Vaginal microbiome, preterm birth, and preeclampsia: A review of current knowledge. Journal of Reproductive Immunology, 125, 35-41.
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  12. Chaban, B., et al. (2014). Characterization of the vaginal microbiota in women with preterm birth: A comparison with women in term birth. PLoS ONE, 9(11), e112434.
  13. Wylie, K. M., et al. (2018). The vaginal microbiome and adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology, 218(3), 324-334.
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  15. MacIntyre, D. A., et al. (2015). The vaginal microbiome during pregnancy and preterm birth. Reproductive Sciences, 22(7), 906-914.

The vaginal microbiome plays a critical role in maintaining vaginal health during pregnancy and is strongly linked to adverse pregnancy outcomes, including preterm birth and preeclampsia. The composition and diversity of the microbiome fluctuate throughout pregnancy, influenced by hormonal changes, environmental factors, and lifestyle. Recent studies have highlighted the importance of certain microbiota, particularly Lactobacillus species, in protecting against infections and inflammation. Conversely, dysbiosis, characterized by a decrease in Lactobacillus dominance, has been associated with an increased risk of preterm birth and preeclampsia. This article explores the current understanding of the vaginal microbiome in pregnancy, its role in preventing pregnancy complications, and future research directions for improving maternal and fetal health.

Keywords : Microbiome, Pregnancy, Vaginal Health, Preterm Birth, Preeclampsia, Lactobacillus, Dysbiosis

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