Three relations compose the Pannexin family of channel forming glycoproteins such as Pannexin-1 (Panx1, Gen-Bank AAQ89382.1, 426 amino-acids), Pannexin-2 (Panx2, Gen-Bank AAI01024.1, 74.4 kDa) and Pannexin-3 (Panx3, Gen-Bank AAK95655.1, 392 aminoacids, 44.7 kDa). Their primary performance is outlined by their capability to make single membrane channels that area unit regulated by post-translational modifications, channel intermixing and sub-cellular expression profiles. Pannexins (Panx) are tetra-spanning membrane proteins that mediate paracrine intercellular communication via release of purines such as ATP or UTP. Pannexins can form non-junctional transmembrane channels for the transport of molecules with a molecular weight of less than 1000 Da. These hemi-channels have been found in the plasma, ER, and Golgi membranes. They can form hemi-channels more easily than connexin subunits and transport Ca2+, ATP, inositol triphosphate, and other small molecules. Pannexins 1 is expressed in: brain, skeletal and heart muscle, testis, ovary. Pannexin 2 are found predominantly in the central nervous system, and for the Pannexin 3, these are involved in several embryonic tissues as well as in adult bone, cartilage and skin.

Keywords : Pannexin Channels, Hemi-Channel, NeuroInflammation, COVID-19 Pathogenesis