Authors :
Joana Kollcaku
Volume/Issue :
Volume 7 - 2022, Issue 10 - October
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3zQAmWj
DOI :
https://doi.org/10.5281/zenodo.7302320
Abstract :
Three relations compose the Pannexin family
of channel forming glycoproteins such as Pannexin-1
(Panx1, Gen-Bank AAQ89382.1, 426 amino-acids),
Pannexin-2 (Panx2, Gen-Bank AAI01024.1, 74.4 kDa)
and Pannexin-3 (Panx3, Gen-Bank AAK95655.1, 392
aminoacids, 44.7 kDa). Their primary performance is
outlined by their capability to make single membrane
channels that area unit regulated by post-translational
modifications, channel intermixing and sub-cellular
expression profiles. Pannexins (Panx) are tetra-spanning
membrane proteins that mediate paracrine intercellular
communication via release of purines such as ATP or
UTP. Pannexins can form non-junctional transmembrane
channels for the transport of molecules with a molecular
weight of less than 1000 Da. These hemi-channels have
been found in the plasma, ER, and Golgi membranes.
They can form hemi-channels more easily than connexin
subunits and transport Ca2+, ATP, inositol triphosphate,
and other small molecules. Pannexins 1 is expressed in:
brain, skeletal and heart muscle, testis, ovary. Pannexin 2
are found predominantly in the central nervous system,
and for the Pannexin 3, these are involved in several
embryonic tissues as well as in adult bone, cartilage and
skin.
Keywords :
Pannexin Channels, Hemi-Channel, NeuroInflammation, COVID-19 Pathogenesis
Three relations compose the Pannexin family
of channel forming glycoproteins such as Pannexin-1
(Panx1, Gen-Bank AAQ89382.1, 426 amino-acids),
Pannexin-2 (Panx2, Gen-Bank AAI01024.1, 74.4 kDa)
and Pannexin-3 (Panx3, Gen-Bank AAK95655.1, 392
aminoacids, 44.7 kDa). Their primary performance is
outlined by their capability to make single membrane
channels that area unit regulated by post-translational
modifications, channel intermixing and sub-cellular
expression profiles. Pannexins (Panx) are tetra-spanning
membrane proteins that mediate paracrine intercellular
communication via release of purines such as ATP or
UTP. Pannexins can form non-junctional transmembrane
channels for the transport of molecules with a molecular
weight of less than 1000 Da. These hemi-channels have
been found in the plasma, ER, and Golgi membranes.
They can form hemi-channels more easily than connexin
subunits and transport Ca2+, ATP, inositol triphosphate,
and other small molecules. Pannexins 1 is expressed in:
brain, skeletal and heart muscle, testis, ovary. Pannexin 2
are found predominantly in the central nervous system,
and for the Pannexin 3, these are involved in several
embryonic tissues as well as in adult bone, cartilage and
skin.
Keywords :
Pannexin Channels, Hemi-Channel, NeuroInflammation, COVID-19 Pathogenesis
