Authors : Maliha Mirza; Syeda Hameda Nishath; Fatima Umaira Saeed

Volume/Issue : Volume 9 - 2024, Issue 4 - April

Google Scholar : https://shorturl.at/c541I

Scribd : https://shorturl.at/h05PR

DOI : https://doi.org/10.38124/ijisrt/IJISRT24APR1387

Abstract : Hypertension, commonly known as high blood pressure, is a chronic condition characterized by persistently elevated pressure within the blood vessels. Defined as blood pressure consistently exceeding 140/90 mmHg, hypertension poses a significant global health threat, affecting hundreds of millions worldwide. The exact cause of hypertension remains complex, a combination of genetic predisposition, environmental factors and lifestyle choices contribute to its development. Age, weight, diet, alcohol consumption, and lack of physical activity are well established risk factors. Development of Hypertension causes end-organ damage.Early diagnosis through regular BP monitoring is essential. Treatment strategies involve lifestyle modification alongside pharmacological treatment in more severe cases. Untreated or poorly controlled hypertension can lead to a cascade of serious complications, including heart attack, stroke, kidney failure. According to JNC- 8, ACC guidelines pharmacological therapy is very effective in maintaining hypertension. These include ACE-i, ARBs, Diuretics, Calcium channel blockers,and Beta-blockers. The global prevalence of hypertension is alarming, with the number of affected individuals projected to rise further in the coming decades. Addressing this public health crisis requires a multi-pronged approach, focusing on public awareness, early diagnosis, effective treatment, and promoting healthy lifestyle choices. Research efforts should continue to unravel the complex mechanisms underlying hypertension and develop novel therapeutic strategies for improved prevention and management.

Keywords : Hypertension, Serious Complications, Lifestyle, Prevention, Management.

References :

1. Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., Grassı, G., Jordan, J., Poulter, N., Rodgers, A., & Whelton, P. K. Hypertension. Nat Rev Dis Primers, March 22, 2018; 4(1). 18014. https://doi.org/10.1038/nrdp.2018.14
2. Kitt, J., Fox, R., Tucker, K. L., & McManus, R. J. New Approaches in Hypertension Management: A Review of Current and Developing Technologies and Their Potential Impact on Hypertension Care. Curr Hypertens Rep, April 25, 2019; 21(6): 44. https:// doi.org/10.1007/s11906-019-0949-4
3. Wolf-Maier K, Cooper RS, Kramer H, Banegas JR, Giampaoli S, Joffres MR, et al. Hypertension treatment and control in five European countries, Canada and the United States. Hypertension. 2004;43(1):10–17. doi: 10.1161/01.HYP. 0000103630.72812.10. [PubMed] [CrossRef] [Google Scholar]
4. Yeruva, K., Akella, R. Hypertension clinical trials. StatPearls - NCBI Bookshelf. April 23, 2023; https://www.ncbi.nlm.nih.gov/books/NBK592421
5. Tackling, G., Borhade, MB., Hypertensive heart disease. StatPearls - NCBI Bookshelf. June 26, 2023; https://www.ncbi.nlm.nih.gov/books/NBK539800/
6. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R., Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002 Dec 14;360(9349):1903-13. [PubMed]
7. Page LB, Damon A & Moellering RC Antecedents of cardiovascular disease in six Solomon Islands societies. Circulation 49, 1132–46 (1974). [PubMed] [Google Scholar]
8. Poulter NR, Prabhakaran D & Caulfield M Hypertension. Lancet 386, 801–812 (2015). [PubMed] [Google Scholar]
9. Hegde, S., Ahmed, I., Aeddula, NR. Secondary hypertension. StatPearls - NCBI Bookshelf. July 30, 2023; https://www.ncbi.nlm.nih.gov/books/NBK544305/ #_article-28819_s3_
10. Kimura G. Glomerular function reserve and sodium sensitivity. Clin Exp Nephrol. 2005 Jun;9(2):102-13. [PubMed]
11. Matuszkiewicz-Rowińska J, Wieliczko M. [Renovascular hypertension]. Wiad Lek. 2015;68(4 Pt 2):623-5. [PubMed]
12. Iqbal, A. M., Jamal, S. F. Essential hypertension. StatPearls - NCBI Bookshelf. July 20, 2023; https://www.ncbi.nlm.nih.gov/books/NBK539859/#_article-21370_s4_
13. Rossi GP, Bisogni V, Rossitto G, Maiolino G, Cesari M, Zhu R, Seccia TM. Practice Recommendations for Diagnosis and Treatment of the Most Common Forms of Secondary Hypertension. High Blood Press Cardiovasc Prev. 2020 Dec;27(6):547-560. [PMC free article] [PubMed]
14. Webster AC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease. Lancet. 2017 Mar 25;389(10075):1238-1252. [PubMed]
15. Toro-Salazar OH, Steinberger J, Thomas W, Rocchini AP, Carpenter B, Moller JH. Long- term follow-up of patients after coarctation of the aorta repair. Am J Cardiol. 2002 Mar 1;89(5):541-7. doi: 10.1016/s0002-9149(01)02293-7. PMID: 11867038.
16. Keser G, Aksu K, Direskeneli H. Takayasu arteritis: an update. Turk J Med Sci. 2018 Aug 16;48(4):681-697. doi: 10.3906/sag-1804-136. PMID: 30114347.
17. Bursi F, Weston SA, Redfield MM, Jacobsen SJ, Pakhomov S, Nkomo VT, Meverden RA, Roger VL. Systolic and diastolic heart failure in the community. JAMA. 2006 Nov 8:296(18):2209-16  [PubMed PMID: 17090767]
18. Gill, R., Goldstein, S. Evaluation and management of perioperative hypertension. StatPearls - NCBI Bookshelf. August 7, 2023 https://www.ncbi.nlm.nih.gov/books/ NBK557830
19. Sundström J, Neovius M, Tynelius P, Rasmussen F. Association of blood pressure in late adolescence with subsequent mortality: cohort study of Swedish male conscripts. BMJ. 2011 Feb 22;342:d643. [PMC free article] [PubMed]
20. SPRINT Research Group. Wright JT, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015 Nov 26;373(22):2103-16. [PMC free article] [PubMed]
21. Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study. Circulation. 1999 Jul 27;100(4):354-60. [PubMed]
22. Kramer K, Kirkman P, Kitzman D, Little WC. Flash pulmonary edema: association with hypertension and reoccurrence despite coronary revascularization. Am Heart J. 2000 Sep;140(3):451-5. [PubMed]