The Study of Polymorphism in Pharmaceutical Operating Processes: Granulation Technique for Carbamazepine Tablets


Authors : Belsarkar AS; Shinde AD; Adsul PS; Dhokale VB.

Volume/Issue : Volume 7 - 2022, Issue 8 - August

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3ARW79a

DOI : https://doi.org/10.5281/zenodo.7027118

- Epilepsy, trigeminal neuralgia, and bipolar disorder are just a few of the conditions that are treated with Carbamazepine, a Dibenzazepine derivative. Firstline treatment for seizures that has exceptional efficacy and is inexpensive is Carbamazepine (CBZ). Due to their high membrane permeability and low water solubility, which make dissolution the rate-limiting step in the absorption process, they are categorised as BCS class II substances by the Biopharmaceutical Classification System. The polymorphic alterations of the drug Carbamazepine are examined in its tablet dosage form by taking into consideration variations in the granulation process or method. To discover the polymorphic alterations in Carbamazepine, a DSC study was conducted for a tablet formulation. This study is set out to investigation to identify the effects of various granulation techniques on the drug Carbamazepine for distinct polymorphic alterations in tablet dosage form.

Keywords : Carbamazepine, Polymorphism, DSC, Variations, Epilepsy, Tablet.

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