Authors : John D.H; Ngeri Bapakaye; Sapira-Ordu L; John A.N.D.; Mba A.G

Volume/Issue : Volume 10 - 2025, Issue 3 - March

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DOI : https://doi.org/10.38124/ijisrt/25mar352

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Abstract : Background: Infertility is a pervasive reproductive health challenge that significantly affects couples in Nigeria, with profound social, emotional, and economic implications. In South-South Nigeria, limited local data exist on the prevalence and etiological trends of infertility, underscoring the need for a focused evaluation in tertiary healthcare settings.  Objective: This study aimed to determine the prevalence, identify the predominant causes, and assess the treatment modalities of infertility among patients at Rivers State University Teaching Hospital (RSUTH).  Methods: A retrospective review of 192 patient records diagnosed with infertility was conducted over a three-year period at RSUTH. Data on demographics, infertility type (primary or secondary), duration, etiological factors, and treatment approaches were extracted from clinical records using a structured pro forma. Statistical analysis was performed using SPSS 21, with significance set at p<0.05.  Results: The patient cohort ranged in age from 21 to over 45 years, with the highest prevalence observed among the 31–35 (34.9%) and 36–40 (31.8%) age groups. Secondary infertility was predominant (83.9%) compared to primary infertility (16.1%). Female factors were notably responsible for most cases, with hyperprolactinaemia (33.9%), tubal factors (13.0%), and anovulation (8.3%) emerging as the leading causes. Male factor infertility accounted for 7.3% of cases, while unexplained infertility was noted in 5.7%. Treatment interventions varied, with bromocriptine (25.0%) and assisted reproductive technology (19.8%) being the most frequently employed modalities.  Conclusion: The study highlights a high prevalence of secondary infertility at RSUTH, predominantly driven by female etiologies, particularly hyperprolactinaemia. These findings reflect both the cultural importance of childbearing in Nigeria and the necessity for comprehensive, multidisciplinary reproductive health services. Further research is warranted to explore long- term outcomes and optimize treatment strategies for infertility in this region.

Keywords : Infertility; Hyperprolactinaemia; Secondary Infertility; Assisted Reproductive Technology.

References :

1. World Health Organization. Infertility [Internet]. World Health Organization. 2024. Available from: https://www.who.int/news-room/fact-sheets/detail/infertility
2. Abebe, M.S., Afework, M. & Abaynew, Y. Primary and secondary infertility in Africa: systematic review with meta-analysis. Fertil Res and Pract 6, 20 (2020). https://doi.org/10.1186/s40738-020-00090-3
3. Esan DT, Nnamani KQ, Ogunkorode A, Muhammad F, Oluwagbemi OO, Ramos CG. Infertility affects the quality of life of Southwestern Nigerian women and their partners. International Journal of Africa Nursing Sciences [Internet]. 2022 Jan 1;17:100506. Available from: https://www.sciencedirect.com/science/article/pii/S2214139122001135
4. Walker MH, Tobler KJ. Female Infertility [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556033/
5. Hosseinirad H, Yadegari P, Falahieh FM, Shahrestanaki JK, Karimi B, Afsharzadeh N, Sadeghi Y. The impact of congenital uterine abnormalities on pregnancy and fertility: a literature review. JBRA Assist Reprod. 2021 Oct 4;25(4):608-616. doi: 10.5935/1518-0557.20210021. PMID: 34224238; PMCID: PMC8489822.
6. Philip OI, Reuben OL, Solomon A. Comparative evaluation of pattern of abnormalities in hysterosalpingography, diagnostic laparoscopy and hysteroscopy among women with infertility in Zaria, Nigeria. International Journal of Medicine and Medical Sciences [Internet]. 2015 Feb 28 [cited 2025 Feb 13];7(2):26–35. Available from: https://academicjournals.org/journal/IJMMS/how-to-cite-article/E7C391251166
7. ‌Daniyal L. Intrauterine Adhesions in Response to Pelvic Inflammatory Disease Due to Change in Vaginal Microecology [Letter]. Int J Womens Health. 2023 Oct 26;15:1623-1624. doi: 10.2147/IJWH.S442745. PMID: 37908285; PMCID: PMC10615102.
8. Izuchukwu A. Okafor, Oluseun O. Saanu, Oladapo Olayemi, Akinyinka O. Omigbodun. Characterization of primary female infertility in a Nigerian tertiary hospital: A case-control study. African Journal of Reproductive Health: 2022; 26 (8):66-82.
9. Adegbola O, Akindele MO. The pattern and challenges of infertility management in Lagos, Nigeria. African Health Sciences: 2014; 13( 4):1126-1129.
10. Dattijo L.M , Andreadis N , Aminu B.M , Umar N.I , Black K.I. The prevalence and clinical pattern of infertility in bauchi, northern, Nigeria. Trop J Obstet Gynaecol, 2016; 33 (1): 76-85.
11.  Larsen U, Masenga G, Mlay J. Infertility in a community and clinic-based sample of couples in Moshi, Northern Tanzania. East Afr Med J. 2006;83(1):10-7.
12. ifeanyi e Menuba, Emmanuel O Ugwu, Samuel N. Obi, Lucky O Lawani, Chidinma I. Onwuka. Clinical management and therapeutic outcome of infertile couples in southeast nigeria. Therapeutics and Clinical Risk Management 2014:10 763–768.
13. Azam Moridi, Nasibeh Roozbeh, Halimeh Yaghoobi, Shirin Soltani, Sareh Dashti, Nasim Shahrahmani, Mojdeh Banaei. Etiology and Risk Factors Associated With Infertility. International Journal of Women’s Health and Reproduction Sciences. 2019; 7(3): 346–353.
14. Deshpande PS, Gupta AS. Causes and prevalence of factors causing infertility in a public health facility. J Hum Reprod Sci 2019;12:287-93.
15. Olatunji AO, Sule-Odu AO. The Pattern of Infertility Cases at a University Hospital. West Afr J Med 2003; 22 (3): 205-207.
16. Panti A, Sununu Y. The profile of infertility in a teaching Hospital in North West Nigeria. Sahel Medical Journal. 2014;17(1):7-11.
17. Umeora OU, Ejikeme BN, Sunday-Adeoyo I, Umeora MC. Sociocul-tural impediments to male factor infertility evaluation in rural South-east Nigeria. J Obstet Gynaecol. 2008;28:323–326.