Malaria is commonly related with more than a few stages of reduced blood counts as revealed by reduced platelets and white cell counts and barely related with hemorrhagic observations or an aspect of disseminated intravascular coagulation. Thrombocytopenia is often seen in falciparum malaria but the exact mechanism for this is unclear. A large and thorough search through peer reviewed publications, conferences, articles and a book was the approach adopted for the review. This review shows the value of low platelet count as an early indicator of acute malaria. The probable mechanism that causes thrombocytopenia in malaria have been discussed to include; A direct interaction between plasmodium and platelets, immune mechanism destruction, destruction of platelets by spleen under the influence of parasite antigen bound to the surface, suppression of thrombopoiesis by parasitic antigen that infiltrate the bone marrow, alteration of splenic function and oxidative stress. It was found out that reduced platelet be counted which tiers from slight to average is a frequent affiliation of the Plasmodium falciparum infection thereby predicting its severity.