GATA 3 immunostainis an important
immune histo chemical stain used in surgical pathology
for the detection of breast and urothelial carcinomas. In
the recently published literature, GATA3 immunostain
positivity has been reported in gallbladder
adenocarcinoma. This study aims to evaluate GATA3
immunostain positivity in gall bladder adenocarcinoma.
Methodology: A cross-sectional observational study was
done on 51 biopsy samples diagnosed with gall bladder
adenocarcinomain the histopathology department of
Chughtai Institute of Pathology.The study was
conducted during January 2021-December 2021.
Monoclonal antibody GATA3 (LOT P58312121,
GeneAb) was applied by manual technique.
Results: GATA3 was applied on 51 cases of gall bladder
adenocarcinoma with positive external control. The
results of our study show negative GATA3immunostain
expression in all cases.
Conclusion: In our study, no single case showed
positivity for GATA3immunostain. Hence, our study
supports that GATA3 immunostain positivity can be
utilized primarily for detection of tumor of breast,
urinary bladder and adnexal origin
Gall bladder adenocarcinoma, GATA3immunostain, breast, urothelial carcinoma, pathology