Authors : Sahil Sorathiya; Dr. Samixa R. Patel

Volume/Issue : Volume 8 - 2023, Issue 11 - November

Google Scholar : https://tinyurl.com/mry7xjbw

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DOI : https://doi.org/10.5281/zenodo.10209895

Abstract : Natural resource-derived compounds have been used in traditional medicine for as long as anybody can remember to influence the wound healing process. In compared to modern pharmaceuticals, these substances have a reduced toxicity potential and fewer side effects. An alcoholic extract of Q. infectoria galls was proven to be helpful in a variety of animal models of inflammation and wound healing. Problems with conventional preparations include the likelihood of drug leftovers remaining after use in patch formulations, which enhances the chance that these remnants will be intentionally abused. Patch preparations are often linked to hypersensitivity, irritation, and blistering. When medications are difficult to stable and may crystallize during storage, there are typically issues with expanding output. Because they are administered with fingers, other semisolid formulations are more prone to cause wound cross-inflammation. These formulations are also more likely to adhere to clothes when the patient is moving. The Spray Film Forming System (SFFS), which has the potential to be effective for a range of wound types, is at the leading edge of wound care technology. Such configurations are beneficial for prolonging the utility of active components, minimizing illness transmission, and promoting quick recovery. Whether the targeted effect is systemic or local, there are various advantages to employing a topical route for medication delivery. Avoiding first-pass metabolism, low pH and enzyme activity in the gastrointestinal system, and a large surface area are all examples. Improvements in therapeutic effectiveness. Because of their efficacy or pharmacokinetic profile, drugs applied to the skin often take the form of a patch, gel, lotion, cream, ointment, or spray. As a result, the goal of this research is to create a film-forming spray that blends natural herbs or old and modern formulations for speedier wound healing. Based on multiple research and reports, ensure that the proper formulation is created by establishing the right concentrations of polymer system and solvent, as well as the right oak gall extraction ratio, to generate the right film-forming spray. Simply mixing film-forming polymers with an active extract of Oak gall (Quercus infectoria) yielded the spray solution. The result was a brilliant yellowish solution. Gall might be taken as a decoction, powder, or poultice, according to traditional sources. They were needed in a variety of situations. These findings support the traditional belief that Q. infectoria has the ability to heal wounds, suggesting that it would be an excellent herbal component to a film-forming spray for wound treatment. The findings of this study back up long-held assumptions regarding what promotes wound healing. The scientific results of the research also gave an explanation for its wound healing qualities. The film forming spray created as a consequence of this endeavor has a skin-friendly pH and produces a film that is smooth, glossy, flexible, opaque, uniform, sticky, and peelable.

Keywords : Film Forming Spray, Oak Gall (Q. Infectoria).