Authors :
Dr. Panaskar A.N; Dr. Panaskar B. A; Mr. Jadhav A.R.; Mr. Godage A.I; Mr. Kale R.P; Ms. Kale S.D
Volume/Issue :
Volume 8 - 2023, Issue 5 - May
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/k5skamr7
DOI :
https://doi.org/10.5281/zenodo.8123034
Abstract :
Coriandrum sativum (C. sativum) is a
medicinal plant traditionally known for its
antispasmodic properties. In this study, we aimed to
evaluate the in-vitro antispasmodic activity of an
aqueous extract of C. sativum leaves on the chicken
ileum. A tissue bath model was used to determine the
potency of the extract in inhibiting acetylcholine-induced
contractions. The antispasmodic activity of the extract
was compared with that of standard antispasmodic
agents such as atropine. Phytochemical analysis was also
conducted to identify the active constituents responsible
for the antispasmodic activity. The results showed that
the aqueous extract of C. sativum leaves exhibited
significant antispasmodic activity on the chicken ileum.
The extract was found to be more potent than atropine
in inhibiting acetylcholine-induced contractions. The
phytochemical analysis revealed the presence of
alkaloids, flavonoids, and tannins, which may be
responsible for the antispasmodic activity of the extract.
These findings suggest that C. sativum could be a
potential source of antispasmodic agents for the
treatment of gastrointestinal disorders associated with
increased intestinal spasms.
Keywords :
Antispasmodic activity, Coriandrum sativum, Aqueous Extract.
Coriandrum sativum (C. sativum) is a
medicinal plant traditionally known for its
antispasmodic properties. In this study, we aimed to
evaluate the in-vitro antispasmodic activity of an
aqueous extract of C. sativum leaves on the chicken
ileum. A tissue bath model was used to determine the
potency of the extract in inhibiting acetylcholine-induced
contractions. The antispasmodic activity of the extract
was compared with that of standard antispasmodic
agents such as atropine. Phytochemical analysis was also
conducted to identify the active constituents responsible
for the antispasmodic activity. The results showed that
the aqueous extract of C. sativum leaves exhibited
significant antispasmodic activity on the chicken ileum.
The extract was found to be more potent than atropine
in inhibiting acetylcholine-induced contractions. The
phytochemical analysis revealed the presence of
alkaloids, flavonoids, and tannins, which may be
responsible for the antispasmodic activity of the extract.
These findings suggest that C. sativum could be a
potential source of antispasmodic agents for the
treatment of gastrointestinal disorders associated with
increased intestinal spasms.
Keywords :
Antispasmodic activity, Coriandrum sativum, Aqueous Extract.
