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Transdermal Drug Delivery for Dermatophytosis: A Novel Approach


Authors : Ajay; Dr. Yogendra Singh; Dr. Ashutosh Upadhayay; Prashant Vashisht

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/43mmhzxz

Scribd : https://tinyurl.com/2zhe4hyu

DOI : https://doi.org/10.38124/ijisrt/26apr2331

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Abstract : Dermatophytosis, also called ringworm, is a common fungal infection that affects the skin, hair, and nails. It is mainly caused by fungi such as Trichophyton, Microsporum, and Epidermophyton. The treatments include topical creams and oral antifungal drugs, but these treatments often do not work effectively. This is because the drugs do not penetrate the skin properly, may cause side effects, and the infection often comes back after treatment. To solve these problems, transdermal drug delivery systems (TDDS) provide a new and effective treatment approach for dermatophytosis. Transdermal delivery helps the drug pass through the skin slowly and in a controlled manner, maintaining a sufficient amount of drug at the infected site while reducing unwanted effects on the body. Several noval carriers such as liposomes, niosomes, ethosomes, nanogels, and microneedle-based patches have been developed to improve the penetration and retention of antifungal drugs in the skin. Research studies have shown that these systems provide better drug absorption, longer drug release, and improved patient comfort and compliance. This review highlights the pathophysiology of dermatophytosis, challenges in conventional treatments, and the potential of novel transdermal systems for effective antifungal therapy.

Keywords : Dermatophytosis, Transdermal Drug Delivery, Antifungal Agents, Nanocarriers, Skin Infection, Controlled Release.

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Dermatophytosis, also called ringworm, is a common fungal infection that affects the skin, hair, and nails. It is mainly caused by fungi such as Trichophyton, Microsporum, and Epidermophyton. The treatments include topical creams and oral antifungal drugs, but these treatments often do not work effectively. This is because the drugs do not penetrate the skin properly, may cause side effects, and the infection often comes back after treatment. To solve these problems, transdermal drug delivery systems (TDDS) provide a new and effective treatment approach for dermatophytosis. Transdermal delivery helps the drug pass through the skin slowly and in a controlled manner, maintaining a sufficient amount of drug at the infected site while reducing unwanted effects on the body. Several noval carriers such as liposomes, niosomes, ethosomes, nanogels, and microneedle-based patches have been developed to improve the penetration and retention of antifungal drugs in the skin. Research studies have shown that these systems provide better drug absorption, longer drug release, and improved patient comfort and compliance. This review highlights the pathophysiology of dermatophytosis, challenges in conventional treatments, and the potential of novel transdermal systems for effective antifungal therapy.

Keywords : Dermatophytosis, Transdermal Drug Delivery, Antifungal Agents, Nanocarriers, Skin Infection, Controlled Release.

Paper Submission Last Date
31 - May - 2026

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