Authors : Marcelo Serrano Valeriano; Luis Gómez Peña

Volume/Issue : Volume 9 - 2024, Issue 12 - December

Google Scholar : https://tinyurl.com/3zf6ccet

Scribd : https://tinyurl.com/pdkv9h8s

DOI : https://doi.org/10.5281/zenodo.14565253

Abstract : The objective of this review article is to compile high-quality information related to the molecular aspects surrounding the parasite Trypanosoma cruzi, to obtain a molecular perspective. The PubMed database was consulted, and this article included documents published within the last five years. Additionally, some older documents with a well- founded and significant basis were considered. Other search filters included the following keywords: molecular aspects of Trypanosoma cruzi, Trypanosoma cruzi immune. The general search results generated 3,286 documents; 2,761 were excluded due to being older than five years, and another 415 were excluded for not being review articles. This left a total of 110 articles for consideration, of which 25 were consulted to support and develop this article. The strategy for searching and selecting relevant articles involved reading the abstracts. The theoretical analysis-synthesis method was used for the search and processing of empirical, theoretical, and methodological information, aiming to break down the information to extract the essential aspects of the subject of study and progressively contribute to solving the scientific problem. This article provides information on different aspects and offers a molecular perspective on the mechanism of action of Trypanosoma cruzi in the human body and how it fights for its survival at the expense of ours.

Keywords : Trypanosoma cruzi, Molecular Aspects, Biological Cycle, Autoimmunity

References :

1. Garcia ES, Gonzales MS, Azambuja P. Biological factors involving Trypanosoma cruzi life cycle in the invertebrate vector, Rhodnius prolixus. Mem. Inst. Oswaldo. 1999;(94): p. 213 - 216.
2. Zingales B. Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity. Acta Tropica. 2018; 184: p. 38 - 52.
3. Flávia Nardy A, Freire-de-Lima G, Morrot A. Immune Evasion Strategies of Trypanosoma cruzi. Journal of Inmunology Research. 2015.
4. Martín-Escolano J, Marín C, Rosales MJ, Tsaousis AD, Medina-Carmona E, Martín-Escolano R. An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment. ACS Publications. 2022; 8(6).
5. Moretti S, Schenkman S, Arruda Mortara R. Trypanosoma cruzi. Trends in Parasitology. 2020; 36(4): p. 404 - 405.
6. Macaluso G, Grippi F, Di Bella S, Blanda V, Gucciardi F, Torina A, et al. A Review on the Immunological Response against Trypanosoma cruzi. Pathongens. 2023; 12(2): p. 282.
7. De Souza W, Barrias ES. May the epimastigote form of Trypanosoma cruzi be infective? Acta Tropica. 2020; 212.
8. Wang W, Peng D, Baptista RP, Li Y, Kissinger JC, Tarleton RL. Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease. Plos Pathogens. 2021; 17(1).
9. Medina-Rincón GJ, Gallo-Bernal S, Jiménez PA, Cruz-Saavedra L, Ramírez D, Rodríguez, et al. Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review. Pathogens. 2021; 10(11): p. 1493.
10. Franzén O, Ochaya S, Sherwood E, Lewis M, Llewellyn M, Miles M, et al. Shotgun Sequencing Analysis of Trypanosoma cruzi I Sylvio X10/1 and Comparison with T. cruzi VI CL Brener. Plos Negleted Tropical Diseases. 2011; 8(5).
11. Zingales B, Bartholomeu C. Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease. Memorias do Instituto Oswaldo Cruz. 2022; 117.
12. Magalhães LMD, Gollob K, Zingales, B, Dutra O. Pathogen diversity, immunity, and the fate of infections: lessons learned from Trypanosoma cruzi human–host interactions. Microbe. 2022; 3(9).
13. Majeau A, Murphy, Herrera C, Dumonteil E. Assessing Trypanosoma cruzi Parasite Diversity through Comparative Genomics: Implications for Disease Epidemiology and Diagnostics. Pathogens. 2021; 10(2).
14. Serrano Valeriano M. Inflammatory Autoimmunity Caused by Lymphoid Cells, Related to Chronic Cardiomyopathy in Patients with Chagas Disease. International Journal of Innovative Science and Research Technology. 2024; 9(11): p. 2622 - 2629.
15. The Oxidative Stress and Chronic Inflammatory Process in Chagas Disease: Role of Exosomes and Contributing Genetic Factors. Oxidative Medicine an Cellular Longevity. 2021.
16. Guimarães-Pinto K, Ferreira, da Costa A, Morrot A, Freire-de-Lim L, Decote- Ricardo D, et al. Cellular Stress and Senescence Induction during Trypanosoma cruzi Infection. Tropical Medicina and Infectious Disease. 2022; 7.
17. Peña-Callejas, González, Jiménez-Cortés. Enfermedad de Chagas: biología y transmisión de Trypanosoma cruzi. 2022.
18. F Lopes M, Matos-Silva T, Vellozo N. Immunopathogenesis in Trypanosoma cruzi infection: a role for suppressed macrophages and apoptotic cells. Frontiers in Immunology. 2023; 14(12).
19. Machado C, Melo. Trypanosoma cruzi: Peripheral Blood Monocytes and Heart Macrophages in the Resistance to Acute Experimental Infection in Rats. Experimental Parasitology. 2001; 97(1).
20. Ichuta Callisaya R, Quispe Claus. Sistema del complemento. Revista de Actualización Clínica Investiga. 2011; 13.
21. Ramírez-Toloza G, Aguilar-Guzmán, Valck, Menon, Ferreira, ¿Ferreira A. Is It Possible to Intervene in the Capacity of Trypanosoma cruzi to Elicit and Evade the Complement System? Frontiers in Immunology. 2021; 12.
22. Campetella O, Buscaglia C, Mucci, Susana Leguizamón M. Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show. Author Manuscript. 2020; 20.
23. Monteiro da Costa K, Marques da Fonseca L, Santos dos Reis, Rodrigues da Costa Santos, Osvaldo Previato J, Mendonça-Previato L, et al. Trypanosoma cruzi trans- Sialidase as a Potential Vaccine Target Against Chagas Disease. Frontiers in Cellular and Infection Microbiology. 2021; 11.
24. Campetella, Buscaglia C. Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2020; 1866(5).
25. Hernández-Torres M, do Nascimento, Cardozo Rebouças, Cassado A, Catarine Matteucci K, Regina D’Império-Lima, et al. Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection. Cell Death & Disease. 2021; 12(7): p. 692.