Type B Aortic Dissection in a Young Patient with Methamphetamine Use: A Case Report


Authors : Walther H. Parra; Juan S. Clavijo; Juan S. Vargas; Hollman E. Parada; Asly J. Lizarazo; Alejandro Aponte R.

Volume/Issue : Volume 10 - 2025, Issue 9 - September


Google Scholar : https://tinyurl.com/55wsybja

Scribd : https://tinyurl.com/43mw235f

DOI : https://doi.org/10.38124/ijisrt/25sep018

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Abstract : We report an uncommon case of Stanford type B aortic dissection in a young woman with recent methamphetamine use and no comorbidities. This case illustrates an atypical presentation of a high-mortality condition and highlights an under-recognized association in the literature. The patient presented to the emergency department with sudden-onset chest pain radiating to the back, associated with dyspnea following methamphetamine use. Physical examination revealed bradycardia and hypoxemia without additional abnormalities. Dyspnea of possible thromboembolic origin was evaluated with chest CT angiography, which incidentally demonstrated a Stanford type B dissection without significant aortic dilation. This case underscores the need to maintain a high index of suspicion for aortic dissection in young patients using sympathomimetic drugs, even in the absence of aortic dilation. Methamphetamine may induce vascular changes that predispose to aortic dissection at smaller-than-expected diameters, challenging traditional diagnostic paradigms.

Keywords : Aortic Dissection; Methamphetamine; Aorta, Thoracic; Emergency Service, Hospital; Cardiovascular Diseases.

References :

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  2. Wako E, LeDoux D, Mitsumori L, Aldea GS. The Emerging Epidemic of Methamphetamine-Induced Aortic Dissections. J Card Surg. 2007;22:390-393.
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  4. Winslow F, Hansen NS, Jensen MB. Vertebral Artery Dissection Related to Amphetamine Abuse. J Cent Nerv Syst Dis. 2020;2:1179573520939340.
  5. Luo B-Y, Zhou J, Guo D, et al. Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ. BBA Mol Basis Dis. 2022;1868(6):166447.
  6. Evangelista A, Isselbacher EM, Bossone E, et al. Insights from the International Registry of Acute Aortic Dissection: a 20-year experience. Circulation. 2018;137(17):1846-1860.
  7. Akasaki Y, Ohishi M. Cerebrovascular and cardiovascular diseases caused by drugs of abuse. Hypertens Res [Internet]. 2020;43(5):363–71.
  8. Pape LA, Tsai TT, Isselbacher EM, et al. Aortic diameter >5.5 cm is not a good predictor of type A aortic dissection. Circulation. 2007;116(10):1120-1127.
  9. Coady MA, Rizzo JA, Hammond GL, et al. Surgical intervention criteria for thoracic aortic aneurysms. Ann Thorac Surg. 1999;67(6):1922-1926.
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We report an uncommon case of Stanford type B aortic dissection in a young woman with recent methamphetamine use and no comorbidities. This case illustrates an atypical presentation of a high-mortality condition and highlights an under-recognized association in the literature. The patient presented to the emergency department with sudden-onset chest pain radiating to the back, associated with dyspnea following methamphetamine use. Physical examination revealed bradycardia and hypoxemia without additional abnormalities. Dyspnea of possible thromboembolic origin was evaluated with chest CT angiography, which incidentally demonstrated a Stanford type B dissection without significant aortic dilation. This case underscores the need to maintain a high index of suspicion for aortic dissection in young patients using sympathomimetic drugs, even in the absence of aortic dilation. Methamphetamine may induce vascular changes that predispose to aortic dissection at smaller-than-expected diameters, challenging traditional diagnostic paradigms.

Keywords : Aortic Dissection; Methamphetamine; Aorta, Thoracic; Emergency Service, Hospital; Cardiovascular Diseases.

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Paper Submission Last Date
31 - December - 2025

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