An ultrasound assisted green synthetic protocol has been developed for synthesis of substituted benzalazines using sonicator probe in aqueous medium. Several conventional synthetic methods are known for Bis-Schiff bases, they however suffer from low yields, long reaction duration, harsh conditions & use of organic solvent medium like alcohol, DCM etc. The ultrasound route offered superior yields & shorter reaction times as compared to conventional methods & went smoothly in aqueous medium as against use of organic solvents. Most of the reactions went to completion with greater than 90% yields within 1 minute as indicated by TLC.
Keywords : Azine, Antifungal, Docking Studies, Lanosterol Demethylase.