Ultrasound Assisted Synthesis, Molecular Docking Studies and in Vitro Biological Activity of Azine Derivatives as Potential Antifungal Agents


Authors : Gokul Ganesan, Sreela Dasgupta, Niloufer K. Kotwal.

Volume/Issue : Volume 4 - 2019, Issue 4 - April

Google Scholar : https://goo.gl/DF9R4u

Scribd : https://bit.ly/2HOZXTH

An ultrasound assisted green synthetic protocol has been developed for synthesis of substituted benzalazines using sonicator probe in aqueous medium. Several conventional synthetic methods are known for Bis-Schiff bases, they however suffer from low yields, long reaction duration, harsh conditions & use of organic solvent medium like alcohol, DCM etc.[2] The ultrasound route offered superior yields & shorter reaction times as compared to conventional methods & went smoothly in aqueous medium as against use of organic solvents. Most of the reactions went to completion with greater than 90% yields within 1 minute as indicated by TLC.

Keywords : Azine, Antifungal, Docking Studies, Lanosterol Demethylase.

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