The biologically active form of vitamin D, 1,25 dihydroxy vitamin D (1,25(OH)2D), and its receptor, vitamin D receptor (VDR), play critical roles in oral immunity and periodontal health. Vitamin D is essential for a range of organ systems; yet, shortage is common, with 30 to 50 percent of the population suffering from it. Vitamin D insufficiency has been linked to not just low mineral bone density/osteoporosis and osteopenia, but also infectious and chronic inflammatory illnesses, according to research. Vitamin D has been linked to periodontal disease due to its effects on bone and mineral metabolism, innate immunity, and various vitamin D receptor gene polymorphisms.

Keywords : Periodontal disease, Vitamin D receptor gene polymorphism, Vitamin D.