Authors :
Dr. Pranav Wasadikar; Dr. M. Ramkumar
Volume/Issue :
Volume 10 - 2025, Issue 3 - March
Google Scholar :
https://tinyurl.com/mpkbh3z3
Scribd :
https://tinyurl.com/msbnfpx3
DOI :
https://doi.org/10.38124/ijisrt/25mar1629
Google Scholar
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Abstract :
This case highlights a rare instance of psychosis induced by occupational exposure to diethyl phthalate, a primary
component in certain liquid mosquito repellents. A 48-year-old male exhibited increased irritability, suspiciousness towards
family members, and forgetfulness. He had a three-year history of occupational exposure to volatile liquid mosquito repellents
containing predominantly diethyl phthalate. Comprehensive evaluations ruled out other causes. MRI revealed toxic
encephalopathy. Mental status examination showed anterograde amnesia, persecutory delusions, irritable affect, impaired
judgment, and lack of insight. The patient was treated with Sodium Valproate (1g) and Olanzapine (20mg), leading to
significant improvement. This case underscores the neuropsychiatric risks associated with prolonged occupational exposure to
diethyl phthalate and highlights the need for further research and awareness.
Keywords :
Diethyl Phthalate, Occupational Exposure, Toxic Encephalopathy, Psychosis, Case Report.
References :
- Safarpour S, Ghasemi-Kasman M, Safarpour S, Darban YM. Effects of Di-2-Ethylhexyl Phthalate on central nervous system functions: A narrative review. Curr Neuropharmacol. 2022;20(4):766-76.
- Weaver JA, Beverly BEJ, Keshava N, Mudipalli A, Arzuaga X, Cai C, et al. Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies. Environ Int. 2020;145:105848.
- EPA. Diethyl Phthalate (DEP) Factsheet. https://www.epa.gov/sites/default/files/2015-04/documents/diethylphathalate.pdf
- CDC. Diethyl Phthalate: Occupational Exposure. https://wwwn.cdc.gov/TSP/PHS/PHS.aspx?phsid=601&toxid=112
This case highlights a rare instance of psychosis induced by occupational exposure to diethyl phthalate, a primary
component in certain liquid mosquito repellents. A 48-year-old male exhibited increased irritability, suspiciousness towards
family members, and forgetfulness. He had a three-year history of occupational exposure to volatile liquid mosquito repellents
containing predominantly diethyl phthalate. Comprehensive evaluations ruled out other causes. MRI revealed toxic
encephalopathy. Mental status examination showed anterograde amnesia, persecutory delusions, irritable affect, impaired
judgment, and lack of insight. The patient was treated with Sodium Valproate (1g) and Olanzapine (20mg), leading to
significant improvement. This case underscores the neuropsychiatric risks associated with prolonged occupational exposure to
diethyl phthalate and highlights the need for further research and awareness.
Keywords :
Diethyl Phthalate, Occupational Exposure, Toxic Encephalopathy, Psychosis, Case Report.