What to Know About the Cost-Effectiveness of Seasonal Malaria Chemoprevention in Endemic Countries: A Systematic Review

Authors : Yaya Togo; Oumar Sangho; Mahamoudou Touré; Hannah Marker; Kassoum Kayentao; Mark McGovern; Hamadoun Sangho; Peter J. Winch; Joshua O. Yukich; Seydou Doumbia

Volume/Issue : Volume 8 - 2023, Issue 10 - October

Google Scholar : https://tinyurl.com/ed6ttk7d

Scribd : https://tinyurl.com/2bcne8v4

DOI : https://doi.org/10.5281/zenodo.10017587

Introduction: Over the past 20 years, malaria incidence and prevalence has fallen in sub-Saharan Africa, mainly thanks to intensified vector control. Seasonal malaria chemoprevention (SMC) for children under five is one of the strategies producing significant results in endemic countries. We synthesized studies on cost and cost- effectiveness of SMC intervention. Methods: Preliminary searches were conducted to identify keywords to be searched across five databases: PubMed, EMBASE, EconLit, Centre for Reviews and Dissemination, and AJOL. Screening was conducted independently by two researchers. Costs data, cost effectiveness estimates, and contextual information were extracted using a standardized form by three reviewers. An analysis and qualitative assessment were performed using the CHEERS checklist. Costs and cost-effectiveness ratios were adjusted to common year (2022) and currency (US Dollar).The initial search identified 1,517 publications; 17 were retained for full-text review.Three ICERs were provided with a ratio ranging from 19 to 128 USD (2020) per malaria case averted and a ratio of 3,938 USD per malaria death averted. Cost-effectiveness ratios provided were from 1 to 146 USD per uncomplicated malaria case averted and 11 to 241 USD per severe malaria case averted. Conclusion: Investments in implementation of SMC are cost-effective, and the evidence is relatively strong. Very few studies have been conducted in the highly endemic countries of the WHO African Region, receiving significant funds for malaria control.

Keywords : Cost, Cost-Effectiveness, Seasonal Malaria Chemoprevention, Systematic Review, Mali.


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