Introduction: Over the past 20 years, malaria incidence
and prevalence has fallen in sub-Saharan Africa, mainly
thanks to intensified vector control. Seasonal malaria
chemoprevention (SMC) for children under five is one of
the strategies producing significant results in endemic
countries. We synthesized studies on cost and cost-
effectiveness of SMC intervention.
Methods: Preliminary searches were conducted to
identify keywords to be searched across five databases:
PubMed, EMBASE, EconLit, Centre for Reviews and
Dissemination, and AJOL. Screening was conducted
independently by two researchers. Costs data, cost
effectiveness estimates, and contextual information were
extracted using a standardized form by three reviewers.
An analysis and qualitative assessment were performed
using the CHEERS checklist. Costs and cost-effectiveness
ratios were adjusted to common year (2022) and currency
(US Dollar).The initial search identified 1,517 publications;
17 were retained for full-text review.Three ICERs were
provided with a ratio ranging from 19 to 128 USD (2020)
per malaria case averted and a ratio of 3,938 USD per
malaria death averted. Cost-effectiveness ratios provided
were from 1 to 146 USD per uncomplicated malaria case
averted and 11 to 241 USD per severe malaria case
Conclusion: Investments in implementation of SMC are
cost-effective, and the evidence is relatively strong. Very
few studies have been conducted in the highly endemic
countries of the WHO African Region, receiving
significant funds for malaria control.
Keywords : Cost, Cost-Effectiveness, Seasonal Malaria Chemoprevention, Systematic Review, Mali.