Authors : Dr. VVT Sai Lekha; Dr. Akanksh Chokkapu; Dr. Sasidhar Rokkam

Volume/Issue : Volume 10 - 2025, Issue 7 - July

Google Scholar : https://tinyurl.com/yjdv63rp

Scribd : https://tinyurl.com/2p9nk63t

DOI : https://doi.org/10.38124/ijisrt/25jul1964

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Abstract : Background: Zinner Syndrome is a rare congenital condition of the male urogenital tract, defined by unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction, resulting from mesonephric duct maldevelopment.  Case Presentation: A 27-year-old male presented with urinary frequency, dysuria, painful ejaculation, and secondary infertility. His history included recurrent urinary tract infections and a solitary kidney. Physical examination revealed a retrovesical mass.  Imaging Findings: Transabdominal ultrasound identified a 5.5-cm left seminal vesicle cyst and absent left kidney. CT urogram confirmed renal agenesis and a non-enhancing retrovesical cyst. Pelvic MRI demonstrated a T1-hyperintense, T2-intermediate cyst with hemorrhagic contents, ejaculatory duct obstruction, and associated prostatitis.  Conclusion: Multimodal imaging, particularly MRI, is essential for diagnosing Zinner Syndrome in young males with urogenital symptoms or infertility. Accurate radiological assessment guides management, ranging from conservative surveillance to surgical intervention.

Keywords : Zinner Syndrome, Renal Agenesis, Seminal Vesicle Cyst, Ejaculatory Duct Obstruction, Magnetic Resonance Imaging, Ultrasound, Computed Tomography.

References :

1. Abakar D, Badi F, Sabiri M, et al. Zinner syndrome. Eur J Case Rep Intern Med. 2021;8(7):002628. doi:10.12890/2021_002628. 
2. Zinner A. Ein Fall von angeborenem Defekt des Ductus deferens nebst Samenblasen-Cyste und Nierenagenesie. Wien Klin Wochenschr. 1914; 27:639–40. 
3. Sharma S, Gupta A, Sharma N, et al. Imaging in Zinner syndrome: a case series. Cureus. 2023;15(12): e49987. doi:10.7759/cureus.49987. 
4. Lal S, Gupta M, Yadav R, et al. Zinner syndrome: a case report and review of literature. J Evid Based Med Healthc. 2020;7(42):2400–2. doi:10.18410/jebmh/2020/480. 
5. Wang S, Wang C, Jiang Y, et al. Zinner syndrome in adult male: a rare case report. Transl Androl Urol. 2024;13(3):355–9. doi:10.21037/tau-23-763. 
6. Pavan N, Bucci S, Mazzon G, et al. Zinner syndrome: a diagnostic challenge. Int Urol Nephrol. 2019;51(6):1007–12. doi:10.1007/s11255-019-02134-7. 
7. Rao A, Sharma S. Role of imaging in Zinner syndrome. Indian J Radiol Imaging. 2021;31(4):987–90. doi: 10.4103/ijri.IJRI_123_21. 
8. Kumar V, Singh R. MRI in Zinner syndrome: diagnostic precision. J Clin Imaging Sci. 2022; 12:45. doi:10.25259/JCIS_45_2022. 
9. Gupta A, Sharma N. Differential diagnosis of pelvic cystic lesions. Radiol Clin North Am. 2020;58(2):345–60. doi: 10.1016/j.rcl.2019.10.007. 
10. Chen H, Li Y. Zinner syndrome with rare malignancies: a case report. Urol Case Rep. 2023; 46:102345. doi: 10.1016/j.eucr.2023.102345. 
11. Patel R, Smith J. Medical management of Zinner syndrome. Urol Ann. 2021;13(2):156–60. doi:10.4103/UA.UA_45_20. 
12. Lee S, Kim T. Surgical outcomes of TURED in Zinner syndrome. J Endourol. 2020;34(7):789–94. doi:10.1089/end.2020.0123.