Authors :
Maha Lhaloui; Mustapha Benhessou; Simohamed Ennachit; Mohammed Elkerroumi
Volume/Issue :
Volume 11 - 2026, Issue 6 - June
Google Scholar :
https://tinyurl.com/3duwk765
Scribd :
https://tinyurl.com/57hfe82h
DOI :
https://doi.org/10.38124/ijisrt/26jun1809
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Triple-negative breast cancers are defined by the absence of hormonal receptor expression (estrogen and
progesterone) as well as the lack of HER2 overexpression. Their marked tendency toward early relapse, combined with
pronounced clinical and biological aggressiveness, confers a high metastatic potential and significant resistance to
conventional therapies. This complexity underscores the need for management strategies grounded in a comprehensive
understanding of their molecular biology.
Keywords :
Triple-Negative Breast Cancer, Chemotherapy, EGFR, PARP).
References :
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- Kyndi M, Sorensen FB, Knudsen H, Overgaard M, Nielsen HM, Overgaard J. Danish Breast Cancer Cooperative Group. Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the danish breast cancer cooperative group. J Clin Oncol 2008;26(9):1419–26.
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- Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. NEJM 2010;363:1938–48.
Triple-negative breast cancers are defined by the absence of hormonal receptor expression (estrogen and
progesterone) as well as the lack of HER2 overexpression. Their marked tendency toward early relapse, combined with
pronounced clinical and biological aggressiveness, confers a high metastatic potential and significant resistance to
conventional therapies. This complexity underscores the need for management strategies grounded in a comprehensive
understanding of their molecular biology.
Keywords :
Triple-Negative Breast Cancer, Chemotherapy, EGFR, PARP).