Authors : Dr. Sabu Paul; Dr. Manjusha Mohanan; Dr. Latha Mary Cherian; Dr. Mary Shimi; Dr. Kristina Sabu

Volume/Issue : Volume 9 - 2024, Issue 12 - December

Google Scholar : https://tinyurl.com/bdmuaape

Scribd : https://tinyurl.com/yc45wt8x

DOI : https://doi.org/10.5281/zenodo.14651339

Abstract : Laminin, a readily recognized basement membrane component, can serve as a marker to ascertain if the basement membrane is intact or degraded as carcinogenesis advances. The intent of this study is to illustrate the disruption in the basement membrane's continuity and establish a correlation with the histological grades of oral squamous cell carcinoma (OSCC). Thirty six formalin fixed and paraffin embedded blocks of previously confirmed OSCC were included in the study. The stain distribution in each OSCC case was observed in the cytoplasm of the cells as well as around the basement membrane of the malignant epithelial islands. A reduced distribution of laminin from well differentiated SCC to moderately differentiated SCC to poorly differentiated SCC was revealed by statistical analysis (P value 0.011). From well differentiated SCC to moderately differentiated SCC to poorly differentiated SCC, the intracytoplasmic staining of laminin progressively increased (P value 0.017). In oral squamous cell carcinomas, a high proportion of laminin 5 γ2 should be regarded as a negative prognostic marker of malignancy and a useful marker for evaluating the histological differentiation and aggressiveness of oral cancer.

Keywords : Laminin, Basement Membrane,Intracytoplasmic Staining, Oral Squamous Cell Carcinoma,

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