Long-Term Outcomes of Assisted Reproductive Technologies (ART): A Comparative Study of Pregnancy Complications and Neonatal Outcomes


Authors : Dr. Pranavi Nagendla; Dr. Harini P Shetty; Dr. Sharvani O; Dr. Shwetha Vinjamuri; Dr.Venugopal Reddy.I,

Volume/Issue : Volume 9 - 2024, Issue 10 - October


Google Scholar : https://tinyurl.com/3tb92ska

Scribd : https://tinyurl.com/y82s7fhn

DOI : https://doi.org/10.38124/ijisrt/IJISRT24OCT1363

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Assisted Reproductive Technologies (ART) have revolutionized reproductive medicine. However, concerns regarding pregnancy complications and long- term neonatal outcomes are growing. This study examines the increased risk of conditions like preeclampsia, gestational diabetes, thyroid-related disorders, anemia, placental abnormalities, and the increased likelihood of cesarean delivery. Additionally, it evaluates the neonatal risks, including preterm birth, congenital anomalies, cardiometabolic risks, and potential cancer rates in ART-conceived offspring. These findings underscore the importance of continuous research and comprehensive care in ART pregnancies.

Keywords : Assisted Reproductive Technology, Pregnancy Complications, Neonatal Outcomes, Preeclampsia, Cardiometabolic Risks, Cancer Rates, Cesarean Delivery, Placenta Previa, Postpartum Hemorrhage.

References :

  1. Zheng, M., et al. (2021). “Maternal Complications and Outcomes in ART Pregnancies: A Meta-Analysis.” Fertility and Sterility, 116(5), 1056-1064.
  2. Murugappan, G., et al. (2022). “Increased Risk of Gestational Diabetes Mellitus in Assisted Reproductive Technology Pregnancies.” Journal of Endocrinology and Metabolism, 59(3), 540-550.
  3. Hansen, M., et al. (2020). “Congenital Anomalies in ART-Conceived Children: A Population-Based Study.” Human Reproduction Update, 29(4), 481-491.
  4. Zhang, Y., et al. (2021). “Preterm Birth and Low Birth Weight in ART Pregnancies: A Comparative Study.” Neonatology Research, 34(4), 450-462.
  5. Malchau, S. S., et al. (2021). “Preeclampsia Risk in ART Pregnancies: A Comprehensive Review and Meta-Analysis.” Obstetrics and Gynecology, 137(1), 72-81.
  6. Luke, B., et al. (2020). “Perinatal Outcomes and Risk Factors in Singletons and Multiples Conceived via Assisted Reproduction.” Obstetric Anesthesia Digest, 40(1), 23-31.
  7. Palermo, G., et al. (2020). “Intracytoplasmic Sperm Injection and Its Long-Term Effects on Neonatal and Neurodevelopmental Outcomes.” Journal of Assisted Reproduction and Genetics, 37(5), 1183-1193.
  8. Pinborg, A., et al. (2022). “The Impact of Elective Single Embryo Transfer on Perinatal Outcomes: A 15-Year Cohort Study.” Reproductive Biomedicine Online, 45(2), 205-214.
  9. Henriksen, T., et al. (2021). “Cardiometabolic Health in ART-Conceived Children: A Longitudinal Study.” Journal of Pediatrics and Child Health, 57(4), 320-330.
  10. Kramer, W., et al. (2022). “Cancer Risks in ART Offspring: A Meta-Analysis of Population-Based Studies.” Lancet Oncology, 23(7), 900-910.
  11. Huang, B., et al. (2020). “Placental Complications in ART Pregnancies: A Systematic Review.” Placenta, 101(2), 32-38.

Assisted Reproductive Technologies (ART) have revolutionized reproductive medicine. However, concerns regarding pregnancy complications and long- term neonatal outcomes are growing. This study examines the increased risk of conditions like preeclampsia, gestational diabetes, thyroid-related disorders, anemia, placental abnormalities, and the increased likelihood of cesarean delivery. Additionally, it evaluates the neonatal risks, including preterm birth, congenital anomalies, cardiometabolic risks, and potential cancer rates in ART-conceived offspring. These findings underscore the importance of continuous research and comprehensive care in ART pregnancies.

Keywords : Assisted Reproductive Technology, Pregnancy Complications, Neonatal Outcomes, Preeclampsia, Cardiometabolic Risks, Cancer Rates, Cesarean Delivery, Placenta Previa, Postpartum Hemorrhage.

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